Evidence for a Hox14 paralog group in vertebrates

  title={Evidence for a Hox14 paralog group in vertebrates},
  author={Thomas P. Powers and Chris T. Amemiya},
  journal={Current Biology},

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Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome

It is demonstrated conclusively that the coelacanth HOX clusters are evolving comparatively slowly and that this taxon should serve as a viable outgroup for interpretation of the genomes of tetrapod species.

A non-tree-based comprehensive study of metazoan Hox and ParaHox genes prompts new insights into their origin and evolution

The analysis suggests that the presence of a single type of Posterior Hox genes (PG9-like) is ancestral to bilaterians, and that new Posterior PGs would have arisen in deuterostomes through independent gene duplications, as well as three possible models for the origin of Hox and ParaHox in early metazoans.

Evolution of Hox gene clusters in deuterostomes

An updated picture of the ancestral repertoires of the different lineages is drawn, a sort of “genome Hox bar-code” for most clades, to infer differential gene or cluster losses and gains that occurred during deuterostome evolution, which might be causally linked to the morphological changes that led to these widely diverse animal taxa.

Hox, ParaHox, ProtoHox: facts and guesses

Opposition views are discussed and it is proposed that the ProtoHox cluster had only two genes, and not four as commonly believed, which may help critical discussion of the evolution of the Hox/ParaHox family in the metazoan kingdom.

No more than 14: the end of the amphioxus Hox cluster

The completion and characterization of the Hox gene content of the single amphioxus Hox cluster, which encompasses 650 kb from Hox1 to Evx, are reported and it is suggested that 14 is the end.

Revisiting the origin of the vertebrate Hox14 by including its relict sarcopterygian members.

The results confirmed the hypotheses previously proposed by other studies that vertebrate Hox14 does not have any amphioxus ortholog, and that none of 1-to-1 pairs of vertebrate and Amphioxus posterior Hox genes, based on their relative location in the clusters, is orthologous.

A PCR survey for posterior Hox genes in amphibians.

The amphioxus genome illuminates vertebrate origins and cephalochordate biology.

The results indicate that the amphioxus genome is elemental to an understanding of the biology and evolution of nonchordate deuterostomes, invertebrate chordates, and vertebrates.

Are the deuterostome posterior Hox genes a fast-evolving class?

  • R. Lanfear
  • Biology
    Advances in experimental medicine and biology
  • 2010
This chapter starts by introducing the posterior Hox genes--their distribution among the animal phyla and the likely sequence of duplications that led to this distribution, and introduces the idea of 'deuterostome posterior flexibility' and examines this hypothesis in light of more recent phylogenetic and genomic work on the Hox cluster.

Two more Posterior Hox genes and Hox cluster dispersal in echinoderms

Incorporating the two neglected Posterior Hox genes into assessments of echinoderm Hox gene complements and organisation shows that these animals in fact have Split (S) Hox clusters rather than simply Disorganized (D) clusters within the Duboule classification scheme.



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A response to Homologuephobia, by Gregory A Petsko, Genome Biology 2001 2:comment1002.1-1002.2, to An apology for orthologs - or brave new memes by Eugene V Koonin, Genome Biology 2001,

Molecular evolution of the HoxA cluster in the three major gnathostome lineages

It is concluded that changes in the pattern of cis-sequence conservation after Hox cluster duplication are more consistent with being the outcome of adaptive modification rather than passive mechanisms that erode redundancy created by the duplication event.

The amphioxus Hox cluster: deuterostome posterior flexibility and Hox14

The mapping and phylogenetic analysis of amphioxus “Posterior Class” Hox genes reveals that these genes are evolving at a faster rate in deuterostomes than in protostomes, a phenomenon the authors term Posterior Flexibility.

Hox cluster genomics in the horn shark, Heterodontus francisci.

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Vertebrate Paleontology and Evolution

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Homeodomain proteins.