Evidence for a-Helices in the Large Intracellular Domain Mediating Modulation of the a 1-Glycine Receptor by Ethanol and G bg s

Abstract

The a1-subunit containing glycine receptors (GlyRs) is potentiated by ethanol, in part, by intracellular Gbg actions. Previous studies have suggested that molecular requirements in the large intracellular domain are involved; however, the lack of structural data about this region has made it difficult to describe a detailed mechanism. Using circular… (More)

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