Evidence for a Functional Second Thymus in Mice

@article{Terszowski2006EvidenceFA,
  title={Evidence for a Functional Second Thymus in Mice},
  author={G. Terszowski and S. M{\"u}ller and C. Bleul and C. Blum and R. Schirmbeck and J. Reimann and L. Pasquier and T. Amagai and T. Boehm and H. Rodewald},
  journal={Science},
  year={2006},
  volume={312},
  pages={284 - 287}
}
The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to… Expand
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  • Developmental and comparative immunology
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