Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation

  title={Evidence for a DNA-relay mechanism in ParABS-mediated chromosome segregation},
  author={Hoong Chuin Lim and Ivan Vladimirovich Surovtsev and Bruno Gabriel Beltran and Fang Huang and Joerg Bewersdorf and Christine Jacobs-Wagner},
The widely conserved ParABS system plays a major role in bacterial chromosome segregation. How the components of this system work together to generate translocation force and directional motion remains uncertain. Here, we combine biochemical approaches, quantitative imaging and mathematical modeling to examine the mechanism by which ParA drives the translocation of the ParB/parS partition complex in Caulobacter crescentus. Our experiments, together with simulations grounded on experimentally… CONTINUE READING
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