Evidence for a DCCD-sensitive component of proximal bicarbonate reabsorption.

@article{Bank1985EvidenceFA,
  title={Evidence for a DCCD-sensitive component of proximal bicarbonate reabsorption.},
  author={Nederlandsche Bank and Hagop S. Aynedjian and Bernd Mutz},
  journal={The American journal of physiology},
  year={1985},
  volume={249 5 Pt 2},
  pages={
          F636-44
        }
}
To examine the possible contribution of active H+ secretion mediated by brush border enzymes to proximal tubule HCO-3 absorption, paired reperfusions of surface proximal convoluted tubules were performed with the inhibitor dicyclohexylcarbodiimide (DCCD). In control studies using a solution devoid of HCO-3 but containing 5.5 mM glucose, 1 mM DCCD had no effect on glucose or fluid (Na+) absorption, suggesting that this inhibitor did not interfere with sodium entry at the brush border or… CONTINUE READING