Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice

@article{Callebert2006EvidenceFA,
  title={Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice},
  author={Jacques Callebert and Juan M. Esteve and Philippe Herv{\'e} and Katell Peoc’h and Claire Tournois and Ludovic Drouet and Jean Marie Launay and Luc Maroteaux},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={317},
  pages={724 - 731}
}
A correlation between high plasma serotonin levels and total pulmonary resistance was reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic hypoxia (10% O2 for more than 3 weeks), wild-type mice develop lung vascular remodeling and pulmonary hypertension. We previously reported that, in contrast, the development of these hypoxia-dependent alterations is totally abolished in mice with permanent (genetic) or transient (pharmacologic) inactivation of the serotonin… 

Figures and Tables from this paper

Sarpogrelate hydrochloride, a serotonin 5HT2A receptor antagonist, ameliorates the development of chronic hypoxic pulmonary hypertension in rats

The administration of SPG ameliorated the development of chronic hypoxia-induced pulmonary hypertension and hypertensive pulmonary vascular changes.

Traumatic shock causes elevation of the serotonin 5-HT2B receptor mRNA level in rat aorta

The data obtained suggest that the observed 5-HT2B receptor overexpression is not related to the increased serotonin-induced vasoconstriction and might cause other vascular pathological changes at traumatic shock.

Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn.

It is concluded that increased 5-HT contributes to high PVR in experimental PPHN through activation of the 5- HT2A receptor and that SSRI infusion further increases PVRIn this model.

Transglutaminase 2-mediated serotonylation in pulmonary hypertension.

  • K. PenumatsaB. Fanburg
  • Biology, Chemistry
    American journal of physiology. Lung cellular and molecular physiology
  • 2014
The present review has tried to address the current understanding of 5-HT metabolism in pulmonary hypertension and relate it to what is currently known about the evolving cellular process of serotonylation.

Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension

It is indicated that tryptophan hydroxylase 1 and peripheral serotonin play an essential role in the development of hypoxia-induced elevations in pulmonary pressures and hypoxIA-induced pulmonary vascular remodeling and, in mice, serotonin has differential effects on the pulmonary vasculature and right ventricular hypertrophy.

Pulmonary hypertension and the serotonin hypothesis: where are we now?

  • M. Maclean
  • Biology, Medicine
    International journal of clinical practice. Supplement
  • 2007
The activity of serotonin receptors, the SERT and Tph1 can all be elevated in clinical and experimental PAH and each offers a potentially unique therapeutic target.

Expression and Function of Serotonin 2A and 2B Receptors in the Mammalian Respiratory Network

A significant role of both receptors in respiratory network modulation is suggested, given the nature of the signaling pathways, and whether intracellular calcium may explain effects observed in the respiratory network.

The serotonin hypothesis of pulmonary hypertension revisited.

There is a wealth of evidence to support a role for serotonin in the pathobiology of PAH and to suggest that serotonin may interact with the bone morphogenetic receptor type II (BMPRII) to provide a 'second hit' risk factor for PAH.
...

References

SHOWING 1-10 OF 42 REFERENCES

5-Hydroxytryptamine and platelets: uptake and aggregation in hypoxic pulmonary hypertensive rats.

Serotonin transporter inhibitors protect against hypoxic pulmonary hypertension.

Data indicate that 5-HTT plays a key role in hypoxia-induced pulmonary vascular remodeling and the effects of serotonin transporter inhibitors on PH in humans deserve investigation.

Effect of a serotonin receptor antagonist on interleukin-6-induced pulmonary hypertension in rats.

Serotonin receptor antagonists could be considered as potentially useful agents for the treatment of chronic thromboembolic PH, as well as for that of primary PH and PH associated with collagen vascular diseases.

Treatment with 5-HT potentiates development of pulmonary hypertension in chronically hypoxic rats.

It is shown that 5-HT potentiates development of pulmonary hypertension in rats exposed to chronic hypoxia and is inhibited by ketanserin and methiothepin.

High Plasma Serotonin Levels in Primary Pulmonary Hypertension: Effect of Long-Term Epoprostenol (Prostacyclin) Therapy

The glycoprotein profile indicates that the platelets of P PH patients were not highly activated but had an accelerated turnover and returned to normal under epoprostenol treatment without change of the elevated plasma serotonin, characteristic of PPH.

Increased release of serotonin from rat ileum due to dexfenfluramine.

It is indicated that dexfenfluramines and its major metabolite d-norfenfluramine can increase serotonin release from the small intestine.

The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functionss⃞

It is demonstrated that, in the 5-HT2B receptor, the C terminus, including the palmitoylation and phosphorylation sites, is absolutely required for proper transduction and internalization, and for the first time, it is shown that the lack of C termini can generate a switch of coupling to Gα13, a reduced NO synthase activation, and an increase in cell proliferation.

Increased plasma serotonin in primary pulmonary hypertension.