Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice

  title={Evidence for a Control of Plasma Serotonin Levels by 5-Hydroxytryptamine2B Receptors in Mice},
  author={Jacques Callebert and Juan M. Esteve and Philippe Herv{\'e} and Katell Peoc’h and Claire Tournois and Ludovic Drouet and Jean Marie Launay and Luc Maroteaux},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={724 - 731}
A correlation between high plasma serotonin levels and total pulmonary resistance was reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic hypoxia (10% O2 for more than 3 weeks), wild-type mice develop lung vascular remodeling and pulmonary hypertension. We previously reported that, in contrast, the development of these hypoxia-dependent alterations is totally abolished in mice with permanent (genetic) or transient (pharmacologic) inactivation of the serotonin… 

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