Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the Epidemic

@inproceedings{BouvinPley2013EvidenceFA,
  title={Evidence for a Continuous Drift of the HIV-1 Species towards Higher Resistance to Neutralizing Antibodies over the Course of the Epidemic},
  author={M{\'e}lanie Bouvin-Pley and Marion Morgand and Alain Moreau and Pauline Jestin and Claire Simonnet and Laurent Tran and C{\'e}cile Goujard and Laurence Meyer and Francis Barin and Martine Braibant},
  booktitle={PLoS pathogens},
  year={2013}
}
We compared the neutralization sensitivity of early/transmitted HIV-1 variants from patients infected by subtype B viruses at 3 periods of the epidemic (1987-1991, 1996-2000, 2006-2010). Infectious pseudotyped viruses expressing envelope glycoproteins representative of the viral quasi-species infecting each patient were tested for sensitivity to neutralization by pools of sera from HIV-1 chronically infected patients and by an updated panel of 13 human monoclonal neutralizing antibodies… CONTINUE READING
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