Evidence for a C-terminal tyrosine residue in human and mouse B-lymphocyte membrane μ chains

@article{Mcilhinney1978EvidenceFA,
  title={Evidence for a C-terminal tyrosine residue in human and mouse B-lymphocyte membrane $\mu$ chains},
  author={R. A. J. Mcilhinney and Neil E. Richardson and Arnold Feinstein},
  journal={Nature},
  year={1978},
  volume={272},
  pages={555-557}
}
THE antigen receptor on the plasma membrane of both human and murine bone marrow-derived (B) lymphocytes has been shown to be mainly monomeric IgM (refs 1–5), but the mechanism of attachment of this IgM is not known. Studies on other membrane proteins (for example, glycophorin6, cytochrome b5, (ref. 7) and probably HLA8) have shown that they are bound to the membrane by means of a hydrophobic polypeptide stretch in the C-terminal region, but secreted IgM heavy chains terminate in an extra… Expand
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The monomeric IgM and IgD molecules on the cell surface of B lymphocytes are generally thought to be integral membrane antigen receptors (1-3). These molecules are believed to be involved inExpand
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Interactions of gamma-immunoglobulins with lipid mono- or bilayers and liposomes. Existence of two conformations of gamma-immunoglobulins of different hydrophobicities.
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References

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Structural studies of a heavy chain from a mouse immunoglobulin M with antibody activity.
TLDR
Comparison of tryptic peptide maps of the immunoglobulin M µ chains with two other mouse µ chains showed a large number of common peptides but the same degree of variability in the remaining peptides as seen in γ and α heavy chains. Expand
Actin associated with purified lymphocyte plasma membrane
TLDR
Results are presented which indicate that actin, or a protein exhibiting a high degree of homology withActin, is a major component of extensively purified lymphocyte plasma membrane from pig and human sources. Expand
A form of cytochrome b5 that contains an additional hydrophobic sequence of 40 amino acid residues.
  • L. Spatz, P. Strittmatter
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1971
TLDR
A species of cytochrome b(5) with a monomer molecular weight of 16,700 has been isolated from rabbit-liver microsomes by a procedure that uses detergents and avoids the use of any proteolytic or lipolytic enzymes, and appears to contain an extremely hydrophobic appendage of 40 amino acids at the N-terminus. Expand
Red cell membrane glycoprotein: amino acid sequence of an intramembranous region.
TLDR
It is proposed that the hydrophobic sequence of approximately 23 residues comprises the intramembranous domain of human erythrocyte glycophorin and is intimately and possibly specifically associated with lipids of the membrane. Expand
Detergent-soluble HLA antigens contain a hydrophilic region at the COOH-terminus and a penultimate hydrophobic region.
  • T. Springer, J. Strominger
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1976
TLDR
The orientation and integration of HLA antigens in the lymphocyte membrane were defined, and the structure suggests that HLAAntigens span the plasma membrane. Expand
Synthesis, surface deposition, and secretion of immunoglobulins by abelson virus-transformed lymphosarcoma cell lines
TLDR
The results suggest that Abelson virus transforms thymus-independent lymphocytes in various stages of maturation and these lymphocytes might be of B cell origin. Expand
IMMUNOGLOBULINS AS CELL RECEPTORS *
TLDR
A preliminary account of immunoglobulins which are demonstrable on the membrane of some cells of the plasma cell series, and particularly interesting in the latter case is the comparison of the membrane immunoglobeulins with the immunoglOBulins present in the cytoplasm. Expand
CELL SURFACE IMMUNOGLOBULIN
TLDR
Similarities between cell surface Ig on normal splenic lymphocytes and Daudi cells suggest that the latter is a neoplasm of bone marrow-derived lymphocytes, and covalent assembly of Ig occurs at or near the time that the molecule becomes part of the plasma membrane. Expand
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Mouse IgM (immunoglobulin M) was selectively and partially reduced and treated with iodo[2-14C]acetate to label the interchain disulphide bridges. The carboxymethylation was studied in some detail.Expand
Complete Amino Acid Sequence of the Mu Heavy Chain of a Human IgM Immunoglobulin
TLDR
The homology of the constant regions of immunoglobulin �, γ, α, and ε heavy chains reveals evolutionary relationships and suggests that two genes code for each heavy chain. Expand
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