Evidence for a 5-HT4 receptor pathway mediating chloride secretion in the rat distal colon.

Abstract

Serotonin (5-HT) is a potent secretagogue of chloride ion (Cl-) and a mediator of diarrhea in the carcinoid syndrome. We investigated the role of the 5-HT4 receptor pathway in mediating 5-HT-induced Cl- secretion that is seen as a rise in short circuit current (Isc) in the Ussing chamber. Rat distal colon was stripped of the muscularis, mounted in Ussing… (More)

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Cite this paper

@article{Budhoo1994EvidenceFA, title={Evidence for a 5-HT4 receptor pathway mediating chloride secretion in the rat distal colon.}, author={M R Budhoo and John M. Kellum}, journal={The Journal of surgical research}, year={1994}, volume={57 1}, pages={44-8} }