Evidence for Significant Overlap between Common Risk Variants for Crohn's Disease and Ankylosing Spondylitis

@inproceedings{Laukens2010EvidenceFS,
  title={Evidence for Significant Overlap between Common Risk Variants for Crohn's Disease and Ankylosing Spondylitis},
  author={Debby Laukens and Michel Georges and C{\'e}cile Libioulle and Cynthia Sandor and Myriam Mni and Bert J K Vander Cruyssen and Harald Peeters and Dirk Elewaut and M De Vos},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND A multicenter genome-wide association scan for Crohn's Disease (CD) has recently reported 40 CD susceptibility loci, including 29 novel ones (19 significant and 10 putative). To gain insight into the genetic overlap between CD and ankylosing spondylitis (AS), these markers were tested for association in AS patients. PRINCIPAL FINDINGS Two previously established associations, namely with the MHC and IL23R loci, were confirmed. In addition, rs2872507, which maps to a locus associated… CONTINUE READING

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