Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast

Abstract

Duplex DNA is replicated in the 5'-3' direction by coordinated copying of leading and lagging strand templates with somewhat different proteins and mechanics, providing the potential for differences in the fidelity of replication of the two strands. We previously showed that in Saccharomyces cerevisiae, active replication origins establish a strand bias in… (More)
DOI: 10.1016/S0960-9822(03)00284-7

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@article{Pavlov2003EvidenceFP, title={Evidence for Preferential Mismatch Repair of Lagging Strand DNA Replication Errors in Yeast}, author={Youri I. Pavlov and Ibrahim M. Mian and Thomas A. Kunkel}, journal={Current Biology}, year={2003}, volume={13}, pages={744-748} }