Evidence for Positive Epistasis in HIV-1

@article{Bonhoeffer2004EvidenceFP,
  title={Evidence for Positive Epistasis in HIV-1},
  author={S. Bonhoeffer and C. Chappey and N. Parkin and J. M. Whitcomb and C. Petropoulos},
  journal={Science},
  year={2004},
  volume={306},
  pages={1547 - 1550}
}
Reproductive strategies such as sexual reproduction and recombination that involve the shuffling of parental genomes for the production of offspring are ubiquitous in nature. However, their evolutionary benefit remains unclear. Many theories have identified potential benefits, but progress is hampered by the scarcity of relevant data. One class of theories is based on the assumption that mutations affecting fitness exhibit negative epistasis. Retroviruses recombine frequently and thus provide a… Expand
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