Evidence for Phenotypic Plasticity in Aggressive Triple-Negative Breast Cancer: Human Biology Is Recapitulated by a Novel Model System

@inproceedings{DAmato2012EvidenceFP,
  title={Evidence for Phenotypic Plasticity in Aggressive Triple-Negative Breast Cancer: Human Biology Is Recapitulated by a Novel Model System},
  author={Nicholas C. D’Amato and Julie Hanson Ostrander and Michelle L. Bowie and Christopher Sistrunk and Alexander Borowsky and Robert Cardiff and Katie E. Bell and Lawrence J. T. Young and Karl Simin and Robin E. Bachelder and Jeffrey J. Delrow and Alyssa C Dawson and Lisa Diane Yee and Krzysztof Mr{\'o}zek and Timothy M. Clay and Takuya Osada and Victoria L. Seewaldt},
  booktitle={PloS one},
  year={2012}
}
Breast cancers with a basal-like gene signature are primarily triple-negative, frequently metastatic, and carry a poor prognosis. Basal-like breast cancers are enriched for markers of breast cancer stem cells as well as markers of epithelial-mesenchymal transition (EMT). While EMT is generally thought to be important in the process of metastasis, in vivo evidence of EMT in human disease remains rare. Here we report a novel model of human triple-negative breast cancer, the DKAT cell line, which… CONTINUE READING
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