Evidence for P2-purinoceptors on human osteoblast-like cells.

  title={Evidence for P2-purinoceptors on human osteoblast-like cells.},
  author={Christof Sch{\"o}fl and K. S. Roy Cuthbertson and Christopher A. Walsh and Christopher J Mayne and Peter H. Cobbold and Alexander Von Zur M{\"u}hlen and Rolf D. Hesch and James A. Gallagher},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  volume={7 5},
ATP released from damaged cells or by controlled secretion could be an important factor in the formation or remodeling of bone. In a variety of other tissues ATP has been shown to control cellular processes by acting on P2-purinoceptors and activating the calcium signaling pathway. Here we demonstrate for the first time that extracellular ATP increases the intracellular free calcium [Ca2+]i concentration in normal human osteoblasts and in SaOS-2 cells, a human osteosarcoma-derived cell line… CONTINUE READING

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