Evidence for Ozone Formation in Human Atherosclerotic Arteries

  title={Evidence for Ozone Formation in Human Atherosclerotic Arteries},
  author={P. Wentworth and J. Nieva and Cindy Takeuchi and R. Galve and A. Wentworth and R. Dilley and G. Delaria and A. Saven and B. Babior and K. Janda and A. Eschenmoser and R. Lerner},
  pages={1053 - 1056}
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be… Expand
226 Citations
In vitro oxidation of LDL by ozone.
  • 3
Do neutrophils produce ozone? An appraisal of current evidence
  • 27
  • Highly Influenced
Effect of ozone produced from antibody-catalyzed water oxidation on pathogenesis of atherosclerosis.
  • 11
  • PDF
Role of oxidative modifications in atherosclerosis.
  • 2,345
  • PDF
Formation of Biologically Active Oxysterols during Ozonolysis of Cholesterol Present in Lung Surfactant*
  • 99
  • PDF
Natural ozone scavenger prevents asthma in sensitized rats.
  • 46
Endogenous Generation of Singlet Oxygen and Ozone in Human and Animal Tissues: Mechanisms, Biological Significance, and Influence of Dietary Components
  • A. Onyango
  • Chemistry, Medicine
  • Oxidative medicine and cellular longevity
  • 2016
  • 36
  • PDF
Cytotoxic effects of oxysterols produced during ozonolysis of cholesterol in murine GT1-7 hypothalamic neurons
  • 30
  • Highly Influenced
Ozone Exposure in Vivo and Formation of Biologically Active Oxysterols in the Lung
  • 55
  • PDF


Atherosclerosis is an inflammatory disease.
  • R. Ross
  • Medicine
  • American heart journal
  • 1999
  • 9,194
Low Density Lipoprotein Oxidation and Its Pathobiological Significance*
  • D. Steinberg
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 1997
  • 1,615
  • PDF
Innate and Adaptive Immunity in the Pathogenesis of Atherosclerosis
  • 997
Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.
  • 1,563
  • PDF
Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens
  • 100
  • PDF
Antibody Catalysis of the Oxidation of Water
  • 206
  • PDF