Evidence for Ozone Formation in Human Atherosclerotic Arteries

  title={Evidence for Ozone Formation in Human Atherosclerotic Arteries},
  author={Paul Jr Wentworth and Jorge J. Nieva and Cindy Takeuchi and Roger Galve and Anita D. Wentworth and Ralph B. Dilley and Giacomo A. Delaria and Alan Saven and Bernard M. Babior and Kim D. Janda and Albert Prof Dr Eschenmoser and Richard A. Lerner},
  pages={1053 - 1056}
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be… 
In vitro oxidation of LDL by ozone.
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An "oxidative response to inflammation" model is proposed as a means of reconciling the response-to-injury and oxidative modification hypotheses of atherosclerosis.
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It is concluded that the evidence for ozone production by neutrophils is not convincing and studies using the same probes to implicate ozone in other biological processes should also be interpreted with caution.
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The potential pathways of formation of singlet oxygen and ozone in vivo are reviewed and some new pathways are proposed, as well as examples of how dietary factors may promote or inhibit their generation and activity.
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Background The fact that low density lipoprotein (LDL) is extremely susceptible to oxidative damage has been known for some time (1, 2), but until quite recently this was primarily a nuisance for the
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