Evidence for Ozone Formation in Human Atherosclerotic Arteries

@article{Wentworth2003EvidenceFO,
  title={Evidence for Ozone Formation in Human Atherosclerotic Arteries},
  author={Paul Jr Wentworth and Jorge J. Nieva and Cindy Takeuchi and Roger Galve and Anita D. Wentworth and Ralph B. Dilley and Giacomo A. Delaria and Alan Saven and Bernard M. Babior and Kim D. Janda and Albert Prof Dr Eschenmoser and Richard A. Lerner},
  journal={Science},
  year={2003},
  volume={302},
  pages={1053 - 1056}
}
Here, we report evidence for the production of ozone in human disease. Signature products unique to cholesterol ozonolysis are present within atherosclerotic tissue at the time of carotid endarterectomy, suggesting that ozone production occurred during lesion development. Furthermore, advanced atherosclerotic plaques generate ozone when the leukocytes within the diseased arteries are activated in vitro. The steroids produced by cholesterol ozonolysis cause effects that are thought to be… 
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