Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis

@inproceedings{Palanisamy2011EvidenceFO,
  title={Evidence for Oxidative Stress and Defective Antioxidant Response in Guinea Pigs with Tuberculosis},
  author={Gopinath S. Palanisamy and Natalie M. Kirk and David F. Ackart and Crystal A. Shanley and Ian M. Orme and Randall J Basaraba},
  booktitle={PloS one},
  year={2011}
}
The development of granulomatous inflammation with caseous necrosis is an important but poorly understood manifestation of tuberculosis in humans and some animal models. In this study we measured the byproducts of oxidative stress in granulomatous lesions as well as the systemic antioxidant capacity of BCG vaccinated and non-vaccinated guinea pigs experimentally infected with Mycobacterium tuberculosis. In non-vaccinated guinea pigs, oxidative stress was evident within 2 weeks of infection as… CONTINUE READING
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