Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain

@article{Parmar1998EvidenceFO,
  title={Evidence for O-dealkylation of 7-pentoxyresorufin by cytochrome P450 2B1/2B2 isoenzymes in brain},
  author={Devendra Parmar and Alok Dhawan and Prahlad Kishore Seth},
  journal={Molecular and Cellular Biochemistry},
  year={1998},
  volume={189},
  pages={201-205}
}
O-dealkylation of 7-pentoxyresorufin (PR) was studied in rat brain to characterise the functional activity specific for cytochrome P450 2B1/2B2 isoenzymes in brain microsomes. Brain microsomes catalyzed the O-dealkylation of PR in the presence of NADPH. Pretreatment with phenobarbital (PB; 80 mg/kg body wt, i.p.× 5 days) resulted in 3-4 fold induction of pentoxyresorufin-O-dealkylase (PROD) activity while 3-methylcholanthrene (MC; 30 mg/kg body wt, i.p. × 5 days) did not produce any significant… CONTINUE READING
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Cytochromes P450: Structure, function and mechanism, Taylor and Francis Ltd

  • DFW Lewis
  • Great Britain,
  • 1996
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