Evidence for Modulation of P-glycoprotein-Mediated Efflux by Methoxypolyethylene Glycol-block-Polycaprolactone Amphiphilic Diblock Copolymers

@article{Zastre2004EvidenceFM,
  title={Evidence for Modulation of P-glycoprotein-Mediated Efflux by Methoxypolyethylene Glycol-block-Polycaprolactone Amphiphilic Diblock Copolymers},
  author={Jason Zastre and John Keith Jackson and Helen Mary Burt},
  journal={Pharmaceutical Research},
  year={2004},
  volume={21},
  pages={1489-1497}
}
AbstractPurpose. The purpose of this study was to investigate the pathways involved in rhodamine 123 (R-123) accumulation enhancement in Caco-2 cells with a low molecular-weight methoxypolyethylene glycol-block-polycaprolactone (MePEG-b-PCL) diblock copolymer. Methods. R-123 accumulation by Caco-2 cells with MePEG17-b-PCL5 was measured in the presence of endocytosis inhibitors or under ATP depletion conditions. Directional flux studies were conducted with cell monolayers on Transwell plates… CONTINUE READING
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Effect of pluronic P123 and F127 block copolymer on P-glycoprotein transport and CYP3A metabolism

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