Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells*

  title={Evidence for MR1 Antigen Presentation to Mucosal-associated Invariant T Cells*},
  author={Shouxiong Huang and Susan Gilfillan and Marina Cella and Michael J. Miley and Olivier Lantz and Lonnie Lybarger and Daved H. Fremont and Ted. H. Hansen},
  journal={Journal of Biological Chemistry},
  pages={21183 - 21193}
The novel class Ib molecule MR1 is highly conserved in mammals, particularly in its α1/α2 domains. Recent studies demonstrated that MR1 expression is required for development and expansion of a small population of T cells expressing an invariant T cell receptor (TCR) α chain called mucosal-associated invariant T (MAIT) cells. Despite these intriguing properties it has been difficult to determine whether MR1 expression and MAIT cell recognition is ligand-dependent. To address these outstanding… 

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