Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases

@article{Grammer1997EvidenceFM,
  title={Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases},
  author={Timothy C. Grammer and John Blenis},
  journal={Oncogene},
  year={1997},
  volume={14},
  pages={1635-1642}
}
The mitogen-activated protein kinases (MAPKs) ERK-1 and ERK-2 are activated by a wide variety of oncogenes and extracellular stimuli. The MAPKs participate in a signalling cascade downstream of growth factor/cytokine receptors, Ras, Raf, and MEK. However, MAPK activation is more complicated than a simple linear pathway, and the evidence presented here supports a model of multiple, temporally distinct pathways converging on MAPK which are differentially utilized by various stimuli and cell types… CONTINUE READING

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