Evidence for Implication of Tryptophan Hydroxylase in the Regulation of Melatonin Synthesis in Ovine Pinealocytes in Culture

Abstract

1. Tryptophan hydroxylase (TPOH) is the first enzyme in the melatonin synthesis pathway and the rate-limiting enzyme in serotonin synthesis. We established in this study an in vitro model of ovine pinealocytes to investigate the role of TPOH in melatonin production. 2. We demonstrated that TPOH is highly expressed both in vivo and in vitro at the protein… (More)
DOI: 10.1023/A:1021011604688

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@article{Privat2002EvidenceFI, title={Evidence for Implication of Tryptophan Hydroxylase in the Regulation of Melatonin Synthesis in Ovine Pinealocytes in Culture}, author={Karen L. Privat and Christine Brisson and Anne Jouvet and Didier Chesneau and J. P. Ravault and Mich{\`e}lle F{\`e}vre-Montange}, journal={Cellular and Molecular Neurobiology}, year={2002}, volume={22}, pages={417-429} }