Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma

@article{Guzman2014EvidenceFH,
  title={Evidence for Heightened Hexokinase II Immunoexpression in Hepatocyte Dysplasia and Hepatocellular Carcinoma},
  author={Grace Guzman and Rohini Chennuri and Alexander K. C. Chan and Bryan A. Rea and Ada R Quintana and Roshan D Patel and Pei-Zhang Xu and Hui Xie and Nissim Hay},
  journal={Digestive Diseases and Sciences},
  year={2014},
  volume={60},
  pages={420-426}
}
Normal hepatocytes exhibit low-affinity hexokinase (glucokinase [HKIV]), but during oncogenesis, there is a switch from HKIV to HKII expression. The aims of this study were to compare the immunoexpression of HKII in non-dysplastic cirrhosis (NDC), liver cell change/dysplasia in cirrhosis (LCD), HCC, and normal liver control tissues, and to correlate HKII expression with clinical and histopathological parameters. Immunohistochemistry was performed on a liver cancer progression tissue array… CONTINUE READING

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