Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.

  title={Evidence for HL-A-linked genes in "juvenile" diabetes mellitus.},
  author={Andrew G. Cudworth and Jennifer Woodrow},
  journal={British medical journal},
  volume={3 5976},
HL-A typing of 150 patients who had developed diabetes mellitus by the age of 30 years showed a significant association with HL-A 8 and W 15. The HL-A genotypes were determined in 17 families in which two or more siblings had this type of diabetes. The zygotic assortment of HL-A haplotypes was found to be significantly disturbed from the expected random pattern, with a reduction in the number of siblings showing no identical haplotypes and an appreciable increase in the number with both… CONTINUE READING

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