Evidence for Distinct Mechanisms in the Shaping of the CD4 T Cell Repertoire in Histologically Distinct Myasthenia Gravis – Associated Thymomas

@article{Stroebel2001EvidenceFD,
  title={Evidence for Distinct Mechanisms in the Shaping
of the CD4 T Cell Repertoire in Histologically Distinct
Myasthenia Gravis – Associated Thymomas},
  author={Philipp Stroebel and Markus Helmreich and Hubert Kalbacher and Hans-Konrad Mueller-Hermelink and Alexander Marx},
  journal={Developmental Immunology},
  year={2001},
  volume={8},
  pages={279 - 290}
}
The major histocompatibility complex (MHC) class II is involved both in thymocyte maturation and peptide presentation and might thus play a key role in the pathogenesis of paraneoplastic myasthenia gravis (MG) in thymomas. To further investigate this issue, we analyzed and scored the expression of epithelial class II expression in 35 thymomas (medullary, MDT; mixed, MXT; cortical and well differentiated thymic carcinoma, CT/WDTC) and correlated it with the histological tumor subtype, prevalence… CONTINUE READING
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