Evidence for Direct Inhibition of MHC-Restricted Antigen Processing by Dexamethasone

@inproceedings{Im2014EvidenceFD,
  title={Evidence for Direct Inhibition of MHC-Restricted Antigen Processing by Dexamethasone},
  author={Sun-A Im and Turmunkh Gerelchuluun and Chong Kil Lee},
  booktitle={Immune network},
  year={2014}
}
Dexamethasone (Dex) was shown to inhibit the differentiation, maturation, and antigen-presenting function of dendritic cells (DC) when added during DC generation or maturation stages. Here, we examined the direct effects of Dex on MHC-restricted antigen processing. Macrophages were incubated with microencapsulated ovalbumin (OVA) in the presence of different concentrations of Dex for 2 h, and the efficacy of OVA peptide presentation was evaluated using OVA-specific CD8 and CD4 T cells. Dex… CONTINUE READING

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