Evidence for Cannabinoid Receptor-Dependent and -Independent Mechanisms of Action in Leukocytes

  title={Evidence for Cannabinoid Receptor-Dependent and -Independent Mechanisms of Action in Leukocytes},
  author={Barbara L F Kaplan and Cheryl E. Rockwell and Norbert E. Kaminski},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={1077 - 1085}
Cannabinoids exhibit immunosuppressive actions that include inhibition of interleukin-2 production in response to a variety of T cell activation stimuli. Traditionally, the effects of these compounds have been attributed to cannabinoid receptors CB1 and CB2, both of which are expressed in mouse splenocytes. Therefore, N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorphenyl)-4-methyl-H-pyrazole-3 carboxyamidehydrochloride (SR141716A), a CB1 antagonist, and N-[(1S)-endo-1,3,3,-trimethyl… 

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