Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions.

Abstract

Metabolism of amiodarone to its N-deethylated derivative was investigated on a bank of human hepatic microsomal fractions, two of them lacking the CYP2D6 isozyme. Michaelis-Menten constants for amiodarone N-deethylation were 0.33 +/- 0.11 microM and 2.38 +/- 0.74 nmol/min/mg for KM and Vmax. The specific involvement of CYP3A gene subfamily in amiodarone N… (More)

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@article{Fabre1993EvidenceFC, title={Evidence for CYP3A-mediated N-deethylation of amiodarone in human liver microsomal fractions.}, author={Guilhem Fabre and Bruce A Julian and Bernard Saint-Aubert and Henry Joyeux and Y. M. Berger}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={1993}, volume={21 6}, pages={978-85} }