Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

@article{Wentworth2002EvidenceFA,
  title={Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation},
  author={Paul Jr Wentworth and Jonathan E Mcdunn and Anita D. Wentworth and Cindy Takeuchi and Jorge J. Nieva and Teresa M. Jones and Cristina Bautista and Julie M. Ruedi and Abel Gutierrez and Kim D. Janda and Bernard M. Babior and Albert Prof Dr Eschenmoser and Richard A. Lerner},
  journal={Science},
  year={2002},
  volume={298},
  pages={2195 - 2199}
}
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen (1O2*) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H2O2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature… 
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311 Citations

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  • A. Onyango
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    Oxidative medicine and cellular longevity
  • 2016
TLDR
The potential pathways of formation of singlet oxygen and ozone in vivo are reviewed and some new pathways are proposed, as well as examples of how dietary factors may promote or inhibit their generation and activity.

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Functional variability of antibodies upon oxidative processes.

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    Nature Reviews Microbiology
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A review of the regulation, generation and actions of these molecular mediators, as well as their roles in resisting infection, updates the reader on these concepts and the topical questions in the field.

Biophotonic hydrogen peroxide production by antibodies, T cells, and T-cell membranes.

...

References

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TLDR
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TLDR
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