Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

@article{Wentworth2002EvidenceFA,
  title={Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation},
  author={Paul Jr Wentworth and Jonathan E Mcdunn and Anita D. Wentworth and Cindy Takeuchi and Jorge J. Nieva and Teresa M. Jones and Cristina Bautista and Julie M. Ruedi and Abel Gutierrez and Kim D. Janda and Bernard M. Babior and Albert Prof Dr Eschenmoser and Richard A. Lerner},
  journal={Science},
  year={2002},
  volume={298},
  pages={2195 - 2199}
}
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen (1O2*) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H2O2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature… 
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312 Citations

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Critical review of the Nox2-dependent cellular processes that potentially contribute to bacterial killing and degradation and to indicate possible targets of pharmacological interventions are provided.

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Functional variability of antibodies upon oxidative processes.

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Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms, leading to the concept that ROS are 'intentionally' generated in these cells with distinctive cellular functions related to innate immunity, signal transduction and modification of the extracellular matrix.
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References

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