Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

@article{Wentworth2002EvidenceFA,
  title={Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation},
  author={P. Wentworth and J. McDunn and A. D. Wentworth and Cindy Takeuchi and J. Nieva and T. Jones and C. Bautista and J. Ruedi and Abel Gutierrez and K. Janda and B. Babior and A. Eschenmoser and R. Lerner},
  journal={Science},
  year={2002},
  volume={298},
  pages={2195 - 2199}
}
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen (1O2*) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H2O2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature… Expand
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Functional variability of antibodies upon oxidative processes.
TLDR
The biological significance of the appearance of new antigen binding specificities on antibodies after exposure to redox-active agents is discussed. Expand
Biophotonic hydrogen peroxide production by antibodies, T cells, and T-cell membranes.
TLDR
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  • Biology, Medicine
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TLDR
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