Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation

@article{Wentworth2002EvidenceFA,
  title={Evidence for Antibody-Catalyzed Ozone Formation in Bacterial Killing and Inflammation},
  author={P. Wentworth and J. McDunn and A. Wentworth and Cindy Takeuchi and J. Nieva and T. Jones and C. Bautista and J. Ruedi and A. Guti{\'e}rrez and K. Janda and B. Babior and A. Eschenmoser and R. Lerner},
  journal={Science},
  year={2002},
  volume={298},
  pages={2195 - 2199}
}
  • P. Wentworth, J. McDunn, +10 authors R. Lerner
  • Published 2002
  • Medicine, Chemistry
  • Science
  • Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen (1O2*) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H2O2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature… CONTINUE READING
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