Evidence for A2 adenosine receptor-mediated effects on adenylate cyclase activity in rat ovarian membranes.

@article{Billig1988EvidenceFA,
  title={Evidence for A2 adenosine receptor-mediated effects on adenylate cyclase activity in rat ovarian membranes.},
  author={H{\aa}kan Billig and Sten Rosberg},
  journal={Molecular and cellular endocrinology},
  year={1988},
  volume={56 3},
  pages={
          205-10
        }
}
Effects of adenosine analogues on adenylate cyclase activity in preovulatory rat ovarian membranes were studied. Adenosine analogues stimulated adenylate cyclase activity in the following rank order of potency: NECA (5'-(N-ethyl)carboxamidoadenosine) greater than 2-chloroadenosine greater than N6-(R-phenylisopropyl)-adenosine greater than N6-(S-phenylisopropyl)adenosine. The apparent EC50 for NECA was 0.28 microM. The adenosine receptor antagonist 8-phenyltheophylline (10 microM) displaced the… CONTINUE READING