Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

@article{Hayashi1998EvidenceF5,
  title={Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport},
  author={T Hayashi and Michael F. Hirshman and E J Kurth and William W. Winder and Laurie J. Goodyear},
  journal={Diabetes},
  year={1998},
  volume={47},
  pages={1369 - 1373}
}
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulinstimulated glucose transport. We have hypothesized that the 5′AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases… 

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TLDR
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TLDR
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TLDR
Results provide evidence that the increase in insulin sensitivity of muscle glucose transport that follows exercise is mediated by activation of AMPK and involves a step beyond PKB in the pathway by which insulin stimulates glucose transport.
AMP-activated protein kinase and muscle glucose uptake.
TLDR
The effects of AMPK on muscle glucose uptake makes this protein a promising pharmacological target for the treatment of type 2 diabetes.
Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
TLDR
The results suggest a possible role for CaMKK as an upstream AMPK kinase in 3T3-L1 adipocytes, in addition to LKB1, and the molecular mechanism of AMPK activation by known stimuli, the acute effect of various AMPK activators on glucose transport, the effect of AM PK inhibition and knockdown on AICAR mediated inhibition of insulin-stimulated glucose transport and the effect on PKB substrate phosphorylation was investigated.
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.
TLDR
Evidence is provided that AMPK signaling is linked to the transcriptional regulation of select metabolic genes in skeletal muscle by a single-leg arterial infusion technique employed in fully conscious rats.
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