Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

@article{Hayashi1998EvidenceF5,
  title={Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport},
  author={T. Hayashi and M. Hirshman and E. Kurth and W. Winder and L. Goodyear},
  journal={Diabetes},
  year={1998},
  volume={47},
  pages={1369 - 1373}
}
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulinstimulated glucose transport. We have hypothesized that the 5′AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases… Expand
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  • 224
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  • 213
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  • 252
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References

SHOWING 1-10 OF 26 REFERENCES
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
  • 936
  • PDF
The Effects of Wortmannin on Rat Skeletal Muscle
  • 321
  • PDF
Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.
  • 216
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.
  • 485
  • PDF
Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle*
  • 407
  • PDF
Exercise regulation of glucose transport in skeletal muscle.
  • 267
  • PDF
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.
  • 780
  • PDF
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase.
  • 244
...
1
2
3
...