Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

@article{Hayashi1998EvidenceF5,
  title={Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport},
  author={T. Hayashi and M. Hirshman and E. Kurth and W. Winder and L. Goodyear},
  journal={Diabetes},
  year={1998},
  volume={47},
  pages={1369 - 1373}
}
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulinstimulated glucose transport. We have hypothesized that the 5′AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases… Expand
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Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.
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Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
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Activation of Glucose ' lhnsport by m-Activated Protein Kinase via Stimulation of Nitric O i d e Synthase
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Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.
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AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle.
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AMP-activated protein kinase and the regulation of glucose transport.
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Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.
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AMP-activated protein kinase and muscle glucose uptake.
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Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
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AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.
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References

SHOWING 1-10 OF 26 REFERENCES
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
  • 936
  • PDF
The Effects of Wortmannin on Rat Skeletal Muscle
  • 321
  • PDF
Insulin activation of acetyl-CoA carboxylase accompanied by inhibition of the 5'-AMP-activated protein kinase.
  • 216
Dual regulation of the AMP‐activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle
  • 322
  • PDF
Contraction stimulates translocation of glucose transporter GLUT4 in skeletal muscle through a mechanism distinct from that of insulin.
  • 485
  • PDF
Contraction-induced Changes in Acetyl-CoA Carboxylase and 5′-AMP-activated Kinase in Skeletal Muscle*
  • 407
  • PDF
Exercise regulation of glucose transport in skeletal muscle.
  • 267
  • PDF
Inactivation of acetyl-CoA carboxylase and activation of AMP-activated protein kinase in muscle during exercise.
  • 780
  • PDF
Electrical stimulation inactivates muscle acetyl-CoA carboxylase and increases AMP-activated protein kinase.
  • 244
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell‐permeable activator of AMP‐activated protein kinase
  • 438
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