Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport

@article{Hayashi1998EvidenceF5,
  title={Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport},
  author={T Hayashi and Michael F. Hirshman and E J Kurth and William W. Winder and Laurie J. Goodyear},
  journal={Diabetes},
  year={1998},
  volume={47},
  pages={1369 - 1373}
}
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulinstimulated glucose transport. We have hypothesized that the 5′AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases… 
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Possible involvement of the alpha1 isoform of 5'AMP-activated protein kinase in oxidative stress-stimulated glucose transport in skeletal muscle.
TLDR
The data suggest that acute oxidative stress activates AMPKalpha1 in skeletal muscle via an AMP-independent mechanism and leads to an increase in the rate of glucose transport, at least in part, through an AM PKalpha1-mediated mechanism.
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
TLDR
It is demonstrated that adenoviral-mediated expression of a constitutively active mutant of AMPK alpha leads to activation of glucose transport in a skeletal-muscle cell line, similar to that seen following treatment with 5-amino-imidazolecarboxamide riboside, hyperosmotic stress or insulin.
Activation of Glucose ' lhnsport by m-Activated Protein Kinase via Stimulation of Nitric O i d e Synthase
TLDR
It is shown that activation of AMPK by AICAR in rat muscle and mouse H-2Kh muscle cells activates glucose transport approximately twofold, and treatment of H- 2Kh cells with NOS inhibitors completely blocks the increase in glucose transport after activation ofAMPK.
Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.
TLDR
The results suggest that AMPK does not mediate contraction- Stimulated glycogen synthesis or glycogenolysis in skeletal muscle and also that acute AMPK activation leads to an increased glycolytic flux by antagonizing contraction-stimulated glycogens synthesis.
AMP-activated protein kinase activity and glucose uptake in rat skeletal muscle.
TLDR
Tetanic contractions of isolated epitrochlearis muscles in vitro significantly increased the activity of both AMPK isoforms in a dose-dependent manner and at a similar rate compared with increases in 3-MG uptake, suggesting the activation of AMPK alpha 2-containing complexes may be more important in regulating exercise-mediated skeletal muscle metabolism in vivo.
AMP-activated protein kinase and the regulation of glucose transport.
TLDR
Evidence that AMPK may play a role in enhancing muscle and whole body insulin sensitivity for glucose transport under conditions such as exercise, as well as the use of the AMPK activator AICAR to reverse insulin-resistant conditions is discussed.
Activation of AMP kinase enhances sensitivity of muscle glucose transport to insulin.
TLDR
Results provide evidence that the increase in insulin sensitivity of muscle glucose transport that follows exercise is mediated by activation of AMPK and involves a step beyond PKB in the pathway by which insulin stimulates glucose transport.
AMP-activated protein kinase and muscle glucose uptake.
TLDR
The effects of AMPK on muscle glucose uptake makes this protein a promising pharmacological target for the treatment of type 2 diabetes.
Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes
TLDR
The results suggest a possible role for CaMKK as an upstream AMPK kinase in 3T3-L1 adipocytes, in addition to LKB1, and the molecular mechanism of AMPK activation by known stimuli, the acute effect of various AMPK activators on glucose transport, the effect of AM PK inhibition and knockdown on AICAR mediated inhibition of insulin-stimulated glucose transport and the effect on PKB substrate phosphorylation was investigated.
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle.
TLDR
Evidence is provided that AMPK signaling is linked to the transcriptional regulation of select metabolic genes in skeletal muscle by a single-leg arterial infusion technique employed in fully conscious rats.
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