Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport
@article{Hayashi1998EvidenceF5, title={Evidence for 5′AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport}, author={T. Hayashi and M. Hirshman and E. Kurth and W. Winder and L. Goodyear}, journal={Diabetes}, year={1998}, volume={47}, pages={1369 - 1373} }
The intracellular signaling proteins that lead to exercise-stimulated glucose transport in skeletal muscle have not been identified, although it is clear that there are separate signaling mechanisms for exercise- and insulinstimulated glucose transport. We have hypothesized that the 5′AMP-activated protein kinase (AMPK) functions as a signaling intermediary in exercise-stimulated glucose uptake. This hypothesis was based on recent studies showing the following: 1) muscle contraction increases… Expand
811 Citations
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