Evidence for 14 homeobox gene clusters in human genome ancestry

@article{Pollard2000EvidenceF1,
  title={Evidence for 14 homeobox gene clusters in human genome ancestry},
  author={Sophie L. Pollard and Peter W. H. Holland},
  journal={Current Biology},
  year={2000},
  volume={10},
  pages={1059-1062}
}
The arrangement of Hox genes into physical clusters is fundamental to the patterning of animal body plans. Other homeobox genes are often described as dispersed, with only occasional examples of linkage reported, such as the amphioxus ParaHox and Drosophila 93D/E clusters. This clustering is unlikely to be the derived condition, as the genes of the ParaHox and 93D/E clusters are phylogenetically widespread. To assess whether clustering is retained in mammals, and to infer its history, we… Expand
Beyond the Hox: how widespread is homeobox gene clustering?
TLDR
It is argued that the ParaHox gene cluster arose early in animal evolution, and duplicated in vertebrates to give the four clusters in human and mouse genomes, and also duplicated to yield four descendent clusters in mammalian genomes. Expand
The NK Homeobox Gene Cluster Predates the Origin of Hox Genes
TLDR
It is shown that Hox genes' origin occurred after the divergence of sponge and eumetazoan lineages and occurred concomitantly with a major evolutionary transition in animal body-plan complexity and the maintenance of the NK cluster in sponges and bilaterians for greater than 550 million years. Expand
Conservation of gene linkage in dispersed vertebrate NK homeobox clusters
TLDR
All of the paralogs of these ancestrally clustered NK genes in several distinct vertebrates are identified and it is demonstrated that tight linkages of Lbx1–Tlx1, LbX2–TLx2 and Nkx3.1–Nkx2.6 have been widely maintained in both the ray-finned and lobe-finning fish lineages. Expand
Evolution of homeobox genes
  • P. Holland
  • Biology, Medicine
  • Wiley interdisciplinary reviews. Developmental biology
  • 2013
TLDR
Genomic data suggest that the ANTP class diversified by extensive tandem duplication to generate a large array of genes, including an NK gene cluster and a hypothetical ProtoHox gene cluster that duplicated to generate Hox and ParaHox genes. Expand
The evolution of homeobox genes: Implications for the study of brain development
TLDR
The homeobox gene superfamily includes many genes implicated in brain development in vertebrates; for example, the Otx, Emx, Dmbx, Gbx, En and Hox gene families, each containing multiple gene families. Expand
Chromosomal mapping of ANTP class homeobox genes in amphioxus: piecing together ancestral genomes
TLDR
It is inferred that clustering of ANTP class homeobox genes evolved just once, during a series of extensive cis‐duplication events of genes early in animal evolution. Expand
Ancient linkage of a POU class 6 and an anterior Hox-like gene in cnidaria: implications for the evolution of homeobox genes.
  • K. Kamm, B. Schierwater
  • Biology, Medicine
  • Journal of experimental zoology. Part B, Molecular and developmental evolution
  • 2007
TLDR
The much tighter linkage of a POU class 6 gene to an anterior Hox-like gene in a cnidarian is possibly the evolutionary echo of an ancestral genomic region from which most metazoan homeobox classes emerged. Expand
Breakup of a homeobox cluster after genome duplication in teleosts
TLDR
It is proposed that this homeobox gene cluster is held together in chordates by the existence of interdigitated control regions that could be separated after locus duplication in the teleost fish. Expand
Dispersal of NK homeobox gene clusters in amphioxus and humans
TLDR
The Drosophila melanogaster genome has six physically clustered NK-related homeobox genes in just 180 kb, which is in marked contrast to the Hox and ParaHox gene clusters, which are compact in amphioxus and vertebrates, but have been disrupted in Dosophila. Expand
EHGbox in the Clitellate Perionyx excavatus
TLDR
The presence of four clusters, the extended Hox, NKL, ParaHox, and EHGbox, arose by successive tandem duplication events from ancestral Homeobox genes early in metazoan evolution are suggested. Expand
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