Evidence for 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) as a proaggregating agent in rat and human platelets.

@article{Agwu1983EvidenceF1,
  title={Evidence for 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) as a proaggregating agent in rat and human platelets.},
  author={D. E. Agwu and Bruce John Holub},
  journal={Canadian journal of physiology and pharmacology},
  year={1983},
  volume={61 8},
  pages={954-5}
}
In view of the established biological role for 1,25-dihydroxycholecalciferol (DHCC) in calcium mobilization and the significance of calcium availability in platelet activation, it was of interest to investigate the potential for DHCC to act as a proaggregating agent. The present results provide evidence that DHCC at a concentration of 0.01 micrograms/microL can both aggregate human platelets and potentiate ADP-induced platelet aggregation. DHCC was also capable of aggregating rat platelets. 

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