Evidence for (+)-cicletanine sulfate as an active natriuretic metabolite of cicletanine in the rat.

  title={Evidence for (+)-cicletanine sulfate as an active natriuretic metabolite of cicletanine in the rat.},
  author={R. Garay and C. Rosati and K. Fanous and M. Allard and E. Morin and D. Lamiable and R. Vistelle},
  journal={European journal of pharmacology},
  volume={274 1-3},
  • R. Garay, C. Rosati, +4 authors R. Vistelle
  • Published 1995
  • Chemistry, Medicine
  • European journal of pharmacology
  • It was previously shown that the urinary sulfo-conjugate metabolite of cicletanine (cicletanine sulfate), and not free cicletanine, is salidiuretic in rats. Here we investigated potential differences between the resolved (+/-) enantiomers of cicletanine sulfate. Two groups of rats (n = 10) received either (+)- or (-)-cicletanine p.o. High performance capillary electrophoresis revealed that the 24-h urinary excretion of (+)-cicletanine sulfate was 5 times higher than that of (-)-cicletanine… CONTINUE READING
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