Evidence-based toxicology: a comprehensive framework for causation.

  title={Evidence-based toxicology: a comprehensive framework for causation.},
  author={Philip S. Guzelian and Michael S. Victoroff and N Christine Halmes and Robert C James and Christopher P Guzelian},
  journal={Human & experimental toxicology},
  volume={24 4},
This paper identifies deficiencies in some current practices of causation and risk evaluation by toxicologists and formulates an evidence-based solution. The practice of toxicology focuses on adverse health events caused by physical or chemical agents. Some relations between agents and events are identified risks, meaning unwanted events known to occur at some frequency. However, other relations that are only possibilities--not known to occur (and may never be realized)--also are sometimes… CONTINUE READING
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