Evidence-based status of second- and third-generation autologous chondrocyte implantation over first generation: a systematic review of level I and II studies.

@article{Goyal2013EvidencebasedSO,
  title={Evidence-based status of second- and third-generation autologous chondrocyte implantation over first generation: a systematic review of level I and II studies.},
  author={Deepak Goyal and Anjali Goyal and Sohrab Keyhani and Eng Hin Lee and James Hoi Po Hui},
  journal={Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association},
  year={2013},
  volume={29 11},
  pages={
          1872-8
        }
}
PURPOSE The purpose of this study was to examine the Level I and II evidence for newer generations of autologous chondrocyte implantation (ACI) versus first-generation ACI and to establish whether the newer generations have overcome the limitations associated with first-generation ACI. METHODS A literature search was carried out for Level I and II evidence studies on cartilage repair using the PubMed database. All the studies that dealt with ACI were identified. Only Level I and II studies… CONTINUE READING

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