Evidence-based sample size calculations based upon updated meta-analysis.

  title={Evidence-based sample size calculations based upon updated meta-analysis.},
  author={A. J. Sutton and Nicola J. Cooper and David E Jones and Paul C. Lambert and John R. Thompson and Keith R. Abrams},
  journal={Statistics in medicine},
  volume={26 12},
Meta-analyses of randomized controlled trials (RCTs) provide the highest level of evidence regarding the effectiveness of interventions and as such underpin much of evidence-based medicine. Despite this, meta-analyses are usually produced as observational by-products of the existing literature, with no formal consideration of future meta-analyses when individual trials are being designed. Basing the sample size of a new trial on the results of an updated meta-analysis which will include it, may… CONTINUE READING

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