Evidence based medicine on the use of botulinum toxin for headache disorders

@article{SchulteMattler2007EvidenceBM,
  title={Evidence based medicine on the use of botulinum toxin for headache disorders},
  author={Wilhelm J Schulte-Mattler and Elke Leinisch},
  journal={Journal of Neural Transmission},
  year={2007},
  volume={115},
  pages={647-651}
}
Botulinum toxin blocks the release of acetylcholine from motor nerve terminals and other cholinergic synapses. In animal studies botulinum toxin also reduces the release of neuropeptides involved in pain perception. The implications of these observations are not clear. Based on the personal experiences of headache therapists, botulinum toxin injections have… CONTINUE READING