Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology

@article{Barnes2011EvidencebasedGF,
  title={Evidence-based guidelines for the pharmacological treatment of schizophrenia: recommendations from the British Association for Psychopharmacology},
  author={Thomas R. E. Barnes},
  journal={Journal of Psychopharmacology},
  year={2011},
  volume={25},
  pages={567 - 620}
}
  • T. Barnes
  • Published 3 February 2011
  • Medicine, Psychology
  • Journal of Psychopharmacology
These guidelines from the British Association for Psychopharmacology address the scope and targets of pharmacological treatment for schizophrenia. A consensus meeting, involving experts in schizophrenia and its treatment, reviewed key areas and considered the strength of evidence and clinical implications. The guidelines were drawn up after extensive feedback from the participants and interested parties, and cover the pharmacological management and treatment of schizophrenia across the various… 

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References

SHOWING 1-10 OF 1,085 REFERENCES

The 2009 schizophrenia PORT psychopharmacological treatment recommendations and summary statements.

TLDR
An extensive literature review was conducted to determine whether the current psychopharmacological treatment recommendations required revision and whether there was sufficient evidence to warrant new treatment recommendations for prespecified outcomes of interest.

BAP updated guidelines: evidence-based guidelines for the pharmacological management of substance abuse, harmful use, addiction and comorbidity: recommendations from BAP

TLDR
The guidelines primarily cover the pharmacological management of withdrawal, short- and long-term substitution, maintenance of abstinence and prevention of complications, where appropriate, for substance abuse or harmful use or addiction as well management in pregnancy, comorbidity with psychiatric disorders and in younger and older people.

The 2009 Schizophrenia PORT Psychopharmacological Treatment Recommendations and Summary Statements

TLDR
An extensive literature review was conducted to determine whether the current psychopharmacological treatment recommendations required revision and whether there was sufficient evidence to warrant new treatment recommendations for prespecified outcomes of interest.

Evidence-Based Guidelines for the Pharmacological Management of Substance Misuse, Addiction and Comorbidity: Recommendations from the British Association for Psychopharmacology

TLDR
These guidelines primarily cover the pharmacological management of withdrawal, shortand longterm substitution, maintenance of abstinence and prevention of complications, where appropriate, in substance misuse, addiction and comorbidity with psychiatric disorders.

Determinants of medication compliance in schizophrenia: empirical and clinical findings.

TLDR
The substantive literature on medication adherence in schizophrenia is reviewed and a modified health belief model within which empirical findings can be understood is described to help inform both pharmacological and psychosocial treatment planning.

Translating research into practice: the Schizophrenia Patient Outcomes Research Team (PORT) treatment recommendations.

TLDR
The PORT Treatment Recommendations provide a basis for moving toward "evidence-based" practice for schizophrenia and identify both the strengths and limitations in the current knowledge base.

Translating the psychopharmacology of antipsychotics to individualized treatment for severe mental illness: a Roadmap.

TLDR
The Roadmap recommendations provide guidance for clinicians on how to fine-tune their psychopharmacologic strategies with antipsychotics to achieve the best outcomes for each individual patient.

Remission in schizophrenia: proposed criteria and rationale for consensus.

TLDR
The first consensus-based operational criteria for symptomatic remission in schizophrenia are based on distinct thresholds for reaching and maintaining improvement, as opposed to change criteria, allowing for alignment with traditional concepts of remission in both psychiatric and nonpsychiatric illness.

Pharmacotherapy of patients with schizophrenia and substance abuse

TLDR
Slight advantages were found for second-generation antipsychotic agents over conventional antipsychotics with regard to improvement of distinct psychopathological symptoms, reduced craving, and greater reduction of substance use in schizophrenia patients.

A summary of the FDA-NIMH-MATRICS workshop on clinical trial design for neurocognitive drugs for schizophrenia.

TLDR
The suggested guidelines represent reasonable starting points for trial design of cognitive-enhancing drugs, with the understanding that new data, subsequent findings, or other methodological considerations may lead to future modifications.
...