Evidence and conjecture about mechanisms of cutaneous disease in photodermatology.

  title={Evidence and conjecture about mechanisms of cutaneous disease in photodermatology.},
  author={Rebecca M. Porter and A V Anstey},
  journal={Experimental dermatology},
  volume={23 8},
Photosensitivity disorders are caused by a variety of mechanisms. Three common themes are as follows: excess chromophore allowing visible light energy to cause photodynamic damage, reduced DNA repair capacity to UV-induced DNA damage, and enhanced sensitivity to light-induced allergens mediated immunologically. Although the cause of each condition may be known, the precise pathogenesis underlying the photosensitivity has taken longer to understand. By focussing on three clinical disorders under… CONTINUE READING
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