Evidence against the acidification hypothesis in cystic fibrosis.

  title={Evidence against the acidification hypothesis in cystic fibrosis.},
  author={Gregory A. Gibson and Warren G Hill and Ora A. Weisz},
  journal={American journal of physiology. Cell physiology},
  volume={279 4},
The pleiotropic effects of cystic fibrosis (CF) result from the mislocalization or inactivity of an apical membrane chloride channel, the cystic fibrosis transmembrane conductance regulator (CFTR). CFTR may also modulate intracellular chloride conductances and thus affect organelle pH. To test the role of CFTR in organelle pH regulation, we developed a model system to selectively perturb the pH of a subset of acidified compartments in polarized cells and determined the effects on various… CONTINUE READING

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