Evidence against Fisher's theory of dominance

@article{Charlesworth1979EvidenceAF,
  title={Evidence against Fisher's theory of dominance},
  author={Brian Charlesworth},
  journal={Nature},
  year={1979},
  volume={278},
  pages={848-849}
}
FISHER'S theory of the evolution of dominance is based on the fact that heterozygotes for rare deleterious alleles, maintained by recurrent mutation from the wild-type allele at the locus, greatly outnumber homozygotes in a random-mating population at equilibrium1. The fitness of a heterozygote carrying a mutant and the wild-type allele can be written as 1 − hs (1  h  0), compared with fitnesses of 1 and 1 − s for wild-type and mutant homozygotes respectively. Fisher postulated that mutant… CONTINUE READING