Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

@inproceedings{Li2015EvidenceTR,
  title={Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?},
  author={Xiao-Hong Li and Yu-xin Xu and Gill Vance and Yun Wang and Long-Bao Lv and Govert J van Dam and Jian-ping Cao and R Alan Wilson and John Pius Dalton},
  booktitle={PLoS neglected tropical diseases},
  year={2015}
}
BACKGROUND Rhesus macaques are unusual among schistosome hosts, self-curing from an established infection and thereafter manifesting solid immunity against a challenge, an ideal model for vaccine development. Previously, the immunological basis of self-cure was confirmed; surviving worms had ceased feeding but how immunological pressure achieved this was unclear. The schistosome esophagus is not simply a conduit for blood but plays a central role in its processing. Secretions from the anterior… CONTINUE READING
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