Evidence-Based Annotation of Gene Function in Shewanella oneidensis MR-1 Using Genome-Wide Fitness Profiling across 121 Conditions

@inproceedings{Deutschbauer2011EvidenceBasedAO,
  title={Evidence-Based Annotation of Gene Function in Shewanella oneidensis MR-1 Using Genome-Wide Fitness Profiling across 121 Conditions},
  author={A. Deutschbauer and Morgan N. Price and Kelly M. Wetmore and Wenjun Shao and Jason K. Baumohl and Zhuchen Xu and Michelle Nadeau Nguyen and Raquel Tamse and Ronald W. Davis and Adam Paul Arkin},
  booktitle={PLoS genetics},
  year={2011}
}
Most genes in bacteria are experimentally uncharacterized and cannot be annotated with a specific function. Given the great diversity of bacteria and the ease of genome sequencing, high-throughput approaches to identify gene function experimentally are needed. Here, we use pools of tagged transposon mutants in the metal-reducing bacterium Shewanella oneidensis MR-1 to probe the mutant fitness of 3,355 genes in 121 diverse conditions including different growth substrates, alternative electron… CONTINUE READING
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