Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma.

@article{Hou2017EvidenceMA,
  title={Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma.},
  author={Shenda Hou and Shiyu Zhou and Zhen Qin and Liu Yang and Xiangkun Han and Shun Yao and Hongbin Ji},
  journal={The American journal of pathology},
  year={2017},
  volume={187 5},
  pages={954-962}
}
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two distinct subtypes of non-small-cell lung carcinoma. Interestingly, approximately 4% to 9% of human non-small-cell lung carcinoma tumors contain mixed adenomatous and squamous pathologies in a single lesion, clinically termed adenosquamous cell carcinoma. More important, these two different pathological components frequently share identical oncogenic mutations, indicative of a potential transition. Indeed, recent data have… CONTINUE READING
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