Everyone loves an underdog: metabolic engineering of the xylose oxidative pathway in recombinant microorganisms

@article{Valdehuesa2018EveryoneLA,
  title={Everyone loves an underdog: metabolic engineering of the xylose oxidative pathway in recombinant microorganisms},
  author={Kris Ni{\~n}o G. Valdehuesa and Kristine Rose M. Ramos and Grace Nisola and Angelo B. Ba{\~n}ares and Rhudith B. Cabulong and Won-keun Lee and Huaiwei Liu and Wook-Jin Chung},
  journal={Applied Microbiology and Biotechnology},
  year={2018},
  volume={102},
  pages={7703-7716}
}
The d-xylose oxidative pathway (XOP) has recently been employed in several recombinant microorganisms for growth or for the production of several valuable compounds. The XOP is initiated by d-xylose oxidation to d-xylonolactone, which is then hydrolyzed into d-xylonic acid. d-Xylonic acid is then dehydrated to form 2-keto-3-deoxy-d-xylonic acid, which may be further dehydrated then oxidized into α-ketoglutarate or undergo aldol cleavage to form pyruvate and glycolaldehyde. This review… CONTINUE READING
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