Everyday clinical experience of alitretinoin in the treatment of severe chronic hand eczema: seven case studies

@article{English2011EverydayCE,
  title={Everyday clinical experience of alitretinoin in the treatment of severe chronic hand eczema: seven case studies},
  author={John English and Robin A. C. Graham-Brown and A de Sica Chapman and Anton B. Alexandroff},
  journal={Clinical and Experimental Dermatology},
  year={2011},
  volume={36}
}
Chronic hand eczema (CHE) is a debilitating and distressing disease for patients, the physical symptoms of which are compounded by psychosocial problems. Alitretinoin is an endogenously occurring physiological vitamin A derivative (retinoid) that possesses strong anti‐inflammatory and immunomodulatory activity. It is currently the only licensed product for severe CHE unresponsive to treatment with potent topical corticosteroids, and has been proven to be highly effective in clinical trials with… Expand
6 Citations
Management of Chronic Hand Eczema.
TLDR
Switching from topical treatments should not be delayed to avoid sensitizations, time off work, and a negative impact on quality of life. Expand
Management of Chronic Hand Eczema.
TLDR
Switching from topical treatments should not be delayed to avoid sensitizations, time off work, and a negative impact on quality of life. Expand
Alitretinoin for the treatment of severe chronic hand eczema
TLDR
Alitretinoin has a favorable overall profile of adverse effects; however, female patients who are at risk of becoming pregnant should follow a strict pregnancy-prevention program due to the teratogenic effects of this drug. Expand
Benefit-risk tradeoff preferences for chronic hand eczema treatments
TLDR
It is demonstrated that patients with CHE rated efficacy improvements associated with treatment of sCHE as more important than eliminating the risks of specific AEs. Expand
Impact of systemic alitretinoin treatment on skin barrier gene and protein expression in patients with chronic hand eczema
TLDR
Systemic alitretinoin has been shown to be effective in patients with CHE who are refractory to topical corticosteroids. Expand
Abordaje terapéutico en el eczema crónico de manos
Resumen El manejo del eczema de manos es complejo, ya que engloba eczemas de etiopatogenia, curso y pronostico muy diferentes; la mayoria de tratamientos disponibles no cuentan con niveles deExpand

References

SHOWING 1-10 OF 10 REFERENCES
Alitretinoin for Severe Chronic Hand Eczema
TLDR
The ERG concluded that, although the evidence presented indicates that alitretinoin is efficacious in the treatment of severe CHE, it gives little indication of alit retinoin’s efficacy relative to likely alternative treatment options or its efficacy and safety in the longer term. Expand
Successful retreatment with alitretinoin in patients with relapsed chronic hand eczema
TLDR
Patients with severe chronic hand eczema (CHE) often respond to therapy with oral alitretinoin (9‐cis retinoic acid), however, the efficacy of alitRetinoin after disease relapse has not been demonstrated. Expand
Oral alitretinoin (9-cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial.
TLDR
Alitretinoin given at well-tolerated doses induced substantial clearing of chronic hand dermatitis in patients refractory to conventional therapy. Expand
Overview of studies of treatments for hand eczema—the EDEN hand eczema survey
TLDR
A large number of interventions ranging from topical steroids to oral ciclosporin are used, but their evidence base and the best methods to assess their efficacy are uncertain. Expand
Hand eczema and quality of life: a population‐based study
TLDR
Health‐related quality of life (HRQoL) is increasingly being measured in dermatology and hand eczema is a common disease in the population and is of interest from a public health perspective. Expand
9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα
TLDR
The identification of a stereoisomer of retinoic acid, 9-cis retinol, which directly binds and activates RXRα, which suggests a new role for isomerization in the physiology of natural retinoids. Expand
Management of chronic hand eczema. Contact Dermatitis
  • 2007
Oral alitretinoin (9cis-retinoic acid) therapy for chronic hand dermatitis in patients refractory to standard therapy: results of a randomized, double-blind, placebo-controlled, multicenter trial
  • Arch Dermatol
  • 2004
Case studies of alitretinoin in the treatment of severe chronic hand eczema