Every methyl counts--epigenetic calculus.

  title={Every methyl counts--epigenetic calculus.},
  author={Annette N. D. Scharf and Axel Imhof},
  journal={FEBS letters},
  volume={585 13},
Histone modifications play an important role in the formation of an epigenetic memory system that maintains cellular identity. Their complex patterns have been suggested to constitute a histone code, which encodes for specific forms of chromatin. According to the histone code hypothesis these specific patterns are passed on from one cell generation to the next. This enables cells to keep a specific gene expression pattern even in absence of the specific transcription factors that initiated the… CONTINUE READING


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