Everolimus in hormone receptor-positive advanced breast cancer: targeting receptor-based mechanisms of resistance.

@article{Shtivelband2013EverolimusIH,
  title={Everolimus in hormone receptor-positive advanced breast cancer: targeting receptor-based mechanisms of resistance.},
  author={Mikhail I Shtivelband},
  journal={Breast},
  year={2013},
  volume={22 4},
  pages={405-10}
}
Although patients with hormone receptor (HR)-positive breast cancer are successfully treated with endocrine therapy, many tumors go on to develop resistance to these agents. Studies have determined that mechanisms of resistance to endocrine therapy are quite complex and can involve a multitude of signal transduction pathways, either through direct association with the estrogen receptor or through cross-talk with other pathways. Preclinical studies have suggested the therapeutic importance of… CONTINUE READING

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