Event-related potential amplitude/intensity slopes predict response to antidepressants.

  title={Event-related potential amplitude/intensity slopes predict response to antidepressants.},
  author={Stephen R. Paige and Denis F. Fitzpatrick and John Patrick Kline and Scott E. Balogh and Shelton E. Hendricks},
  volume={30 4},
We measured event-related potential (ERP) component amplitudes to four intensities of randomly presented tones. Patients diagnosed with major depressive disorder were tested prior to and following a clinical trial of antidepressant medication. Slope of P2 amplitude as a function of stimulus intensity was calculated for each subject and condition. Subjects were divided into two groups (responders and nonresponders) based on their Hamilton Rating Scale for depression scores following treatment… 
Prediction of treatment response in major depression: integration of concepts.
Electrocortical Features of Depression and Their Clinical Utility in Assessing Antidepressant Treatment Outcome
  • N. Jaworska, A. Protzner
  • Psychology, Biology
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 2013
This review aims to highlight the most consistently noted EEG and ERP features in MDD, which may one day assist with diagnostic confirmation, as well as the potential clinical utility of specific electrocortical measures in aiding with response prediction.
Response prediction to antidepressants using scalp and source-localized loudness dependence of auditory evoked potential (LDAEP) slopes
Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorder.
Findings suggest that target P3b amplitude and P2 amplitude/intensity slope abnormalities reflect different pathophysiological processes.
Predictors of Therapeutic Response to Treatments for Depression: A Review of Electrophysiologic and Dichotic Listening Studies
There are few clinical or biologic predictors of response to treatments for depression, but growing evidence that electrophysiologic and neurocognitive measures of brain function may be of value as predictor of therapeutic response to antidepressants.
Electroencephalography-derived biomarkers of antidepressant response.
  • D. Iosifescu
  • Psychology, Biology
    Harvard review of psychiatry
  • 2011
A growing body of evidence suggesting that several electroencephalography (EEG)-based methods may be useful for predicting antidepressant response and eventually for guiding clinical treatment decisions is reviewed.